血管内皮生长因子及其受体表达和侵袭性垂体腺瘤血管生成关系的研究

Study on the expression of vascular endothelial growth factor, Flt-1 and angiogenesis in invasive pituitary adenomas

目的研究血管内皮生长因子(VEGF)及其受体Flt-1在人垂体腺瘤中的表达,探讨其表达变化、微血管密度(MVD)与侵袭性垂体腺瘤血管生成的关系。方法采用免疫组织化学技术检测52例垂体腺瘤的VEGF及其受体表达水平,同时检测CD34表达,用于测定垂体腺瘤的MVD,比较其在侵袭性和非侵袭性垂体腺瘤中的差异。结果VEGF及其受体和MVD与垂体腺瘤的侵袭性密切相关(P<0.01)。结论VEGF可能通过促进新生血管形成刺激垂体腺瘤生长和侵袭,其作用机制有待进一步研究。

Objective To study the expression of vascular endothelial growth factor （VEGF） and its receptor （Flt-1）, and to explore the relationship among the expression, microvessel density （MVD） and angiogenesis in invasive pituitar）, adenomas. Methods Fifty-two surgical samples of pituitary adenomas were stained immumohistochemically with antibodies of VEGF and Flt-1 to investigate their expression, and MVD was assayed by detecting the expression of CD34, A comparison analysis was made to find the difference between invasive pituitary adenomas and non-invasive pituitary adenomas. Results Both VEGF and its receptor, as well as MVD highly correlated with the invasiveness of pituitary adenomas （ P 〈 0. 01 ）. Conclusion VEGF may play an important role in invasiveness of pituitary by promoting tumor angiogenesis. The mechanism needs to be studied further.