慢性乙型肝炎患者HLADRB1等位基因多态性与干扰素抗病毒治疗应答的相关性研究

Association of HLA - DRB_1 alleles with response to interferon -α therapy in chronic hepatitis B

探讨HLA-DRB1等位基因对慢性乙型肝炎α-干扰素抗病毒治疗应答的影响。用序列特异型引物多 聚酶链反应测定山东地区126例慢性乙型肝炎患者和76例对照的HLA-DRB1*03、*07、*09、*12、*15等位基 因。慢乙肝组HIA-DRB1*07等位基因阳性率显著高于正常对照组(P<0．025)。α-干扰素治疗无应答组HLA- DRB1*07阳性率明显高于应答组。在慢性乙型肝炎中HLA-DRB1*07高阳性率与α-干扰素治疗低应答率有密 切的关系。

To investigate the influence of HLA- DRBI alleles on response to interferon- α therapy in chronic hepatitis B. HLA - DRBI ＊ 03, ＊ 07, ＊ 09, ＊ 12, ＊ 15 alleles were determined by using the polymerase chain reaction/sequence specific primer （PCR/SSP）technique in 126 patients with chronic hepatitis B and 76 normal control subjects in Shandong area. The positivities of HLA- DRB1 ＊ 07 allele in the chronic hepatitis B group were significantly higher than that in the normal control group （ P 〈 0.025）. The positivities of HLA- DRB1 ＊ 07 allele were significantly higher in non- responders than those in responders. High positivities of HLA - DRB1 ＊ 07 allele were closely associated with the lower response to interferon - α therapy in chronic hepatitis B.