慢性肝病肝纤维化程度的非侵入性诊断

The noninvasive diagnosis and sensitivity of hepatic fibrosis in patients with chronic liver disease

探讨慢性肝病患者肝纤维化的非侵入性诊断、灵敏度等。对80例慢性肝病患者进行彩色多普勒超声 检查,检测肝动脉收缩期最大流速／门静脉流速比值(A／P)、肝动脉阻力指数(RI),并同时测定血透明质酸(HA)、凝 血酶原指数。肝硬化患者A／P、RI、HA水平显著高于慢性肝病和正常对照组,P<0．05;凝血酶原指数显著低于慢 性肝病和正常对照组,P<0．05。A／P、RI、HA、凝血酶原指数对慢性肝病肝纤维化程度的非侵入性诊断有一定的指 导意义。

To study the noninvasive diagnosis and sensitivity of hepatic fibrosis in Patients with chronic liver disease. The maximum velocity of blood at the portal vein and hepatic artery and RI were measured in 80 cases with chronic liver diseases by Doppler ultrasonography,and hyaluronate acid and prothrom index were recorded at the same time. The levels of A/P ratio, RI, HA in liver cirrhosis were higher significantly than those of chronic hepatitis B and normal control （ P 〈 0.05）. Tnc level of prothrom index in liver cirrhosis were lower significantly than that of chronic hepatitis B and normal control （P 〈 0.05）. A/P ratio, RI, HA and prothrom index may be used for the noninvasive diagnosis of degree of hepatic fibrosis in patients with chronic liver disease.