加替沙星治疗老年肺结核合并下呼吸道感染疗效观察

The clinical observation on treatment effect of gatifloxacin for the gerontism tuberculosis affiliate lower respiratory infection cases

目的观察加替沙星治疗老年肺结核合并下呼吸道感染病人的临床疗效.方法选取63例老年肺结核合并下呼吸道感染病人随机分为2组,观察组34例,予加替沙星每日400 mg静点;对照组29例,予环丙沙星每日400 mg静点,疗程均为7～14 d.结果显示观察组有效率85.3%,对照组有效率62.1%,2组间有显著性差异(P<0.05),观察组临床疗效明显优于对照组;观察组细菌清除率78.6%,对照组细菌清除率60.9%,2组间无显著性差异(P>0.05).结论对老年肺结核合并下呼吸道感染病人选用加替沙星治疗有一定的临床应用价值.

Objective To observe the clinical therapeutic effects of Gatifloxacin forthose patients with gerontism tuberculosis affiliate lower respiratory infection. Method A total of 63 cases chosen in a randomized way were divided into two groups： the study group （n = 34） and the control group （n = 29）.The treatment measures were quiescent point Gatifloxacin and Ciprofloxacin with 400 mg does everyday for the study and control groups respectively. The course of treatment was all 7 - 14 day. Results The effective rate in study group was 85.3 % and in the control group was 62.1% . The difference of two groups was significance （ P 〈 0.05） . The therapeutic effects in study group was better obviously than that in the control group （ P 〈 0.05 ）. The bacterialogical negative conversion rate in study group was 78.6% and in the control group was 60.9%. The difference of two groups were not significance（ P 〉 0.05）. Conclusion The therapeutic effects of Gatifloxacin was perfect for the patients with gerontism tuberculosis affiliate lower respiratory infection and it was significant on clinical application.