同种异体肾移植的HLA配型效果观察

Clinical significance of HLA-matching in renal transplantation recipients

目的:探讨同种异体肾移植的HLA配型效果.方法:比较同种异体肾移植中采用传统HLA配型方法与CREG配型方法的移植状况;对比HLA配型组和未配型组1年移植效果的不同.结果:HLA抗原出现频率较高的有HLA-A2、A11、A24、B60(40)、B13、DR15、DR51、DR52、DR53、DR 4.根据HLA 6位点相配原则,0～6个位点错配(mismatch,MM)所占比例分别为0.78%、1.56%、5.06%、10.12%、27.63%、29.96%和24.9%;而采用交叉组间配型原则(CREGs),0～6位点错配率分别为3.89%、6.23%、17.51%、33.85%、19.84%、13.23%、5.45%.结论:具有某些HLA位点的受者相对来说有更多的获得良好HLA配型的机会;CREGs配型原则明显提高了供、受者间的相配率,但移植效果仍有争议.

Objective： lo evaluate the clinical slgnificance of HLA matching in renal transplantation recipients. Methods： HLA antigen types of 573 patients were analyzed and used to select appropriate donors. The outcomes of HI,A matching and that of GREG were compared in renal transplant recipients. Results： The higher frequency of occurrence of HI,A antigen were A2. A11, A24, B60（40）. B13. I）R15. DRS1. DR52. DR53 . DRI. and the re cipients with these antigens have more opportunity to gain well HLA matching. The proportion of 0. 1. 2. 3. 4. 5. 6 MM were0,78%, 1.56%, 5.06%, 10.12%, 27.63%, 29.96% and 24.9% respectively. Bttt by （＇REG. the proportion was 3.89%, 6,23%. 17,51%, 33.85%,19.84%.13.23%,5,45%, Conclusions：There was no difference between HLA typing and CREG in the incidence of acute rejection and graft survival.