摘要
目的:探讨同种异体肾移植的HLA配型效果.方法:比较同种异体肾移植中采用传统HLA配型方法与CREG配型方法的移植状况;对比HLA配型组和未配型组1年移植效果的不同.结果:HLA抗原出现频率较高的有HLA-A2、A11、A24、B60(40)、B13、DR15、DR51、DR52、DR53、DR 4.根据HLA 6位点相配原则,0~6个位点错配(mismatch,MM)所占比例分别为0.78%、1.56%、5.06%、10.12%、27.63%、29.96%和24.9%;而采用交叉组间配型原则(CREGs),0~6位点错配率分别为3.89%、6.23%、17.51%、33.85%、19.84%、13.23%、5.45%.结论:具有某些HLA位点的受者相对来说有更多的获得良好HLA配型的机会;CREGs配型原则明显提高了供、受者间的相配率,但移植效果仍有争议.
Objective: lo evaluate the clinical slgnificance of HLA matching in renal transplantation recipients. Methods: HLA antigen types of 573 patients were analyzed and used to select appropriate donors. The outcomes of HI,A matching and that of GREG were compared in renal transplant recipients. Results: The higher frequency of occurrence of HI,A antigen were A2. A11, A24, B60(40). B13. I)R15. DRS1. DR52. DR53 . DRI. and the re cipients with these antigens have more opportunity to gain well HLA matching. The proportion of 0. 1. 2. 3. 4. 5. 6 MM were0,78%, 1.56%, 5.06%, 10.12%, 27.63%, 29.96% and 24.9% respectively. Bttt by ('REG. the proportion was 3.89%, 6,23%. 17,51%, 33.85%,19.84%.13.23%,5,45%, Conclusions:There was no difference between HLA typing and CREG in the incidence of acute rejection and graft survival.
出处
《临床泌尿外科杂志》
2005年第10期599-602,共4页
Journal of Clinical Urology
关键词
肾移植
组织配型
Transplantation of kidney
HLA antigen