海洋真菌多糖YCP对小鼠扶正减毒作用的研究

Study of YCP on the Reducing Toxicity of the Radiochemotherapy and Promotion on the Immune System

从海洋真菌YC中提取的真菌多糖YCP,选择9,3,1 mg/kg的不同剂量,分别联合60Co放疗和Cy化疗正常小鼠和Heps荷瘤鼠,观察药物对放、化疗的减毒作用。以荷瘤小鼠观察药物对小鼠的扶正作用。结果:YCP(9,3,1 mg/kg)剂量组可显著地对抗由大剂量Cy造成的正常小鼠外周血白细胞,骨髓有核细胞数和胸腺指数的下降(P<0.01,P<0.05)。YCP(9,3 mg/kg)剂量组可显著地抑制由大剂量Cy和60Co照射造成的Heps荷瘤小鼠外周血白细胞,骨髓有核细胞数和脾脏指数和胸腺指数的下降(P<0.01,P<0.05)。YCP(9,3 mg/kg)可显著提高S180荷瘤小鼠的吞噬指数k和血清半数溶血值(P<0.01,P<0.05)。结论YCP可明显对抗由60Co照射,大剂量化疗药Cy引起的正常和荷瘤小鼠的血液和骨髓抑制毒性。YCP可显著提高S180荷瘤小鼠免疫功能。

The effect of YCP （a kind of polysacchride prepared from a marine fugal named YC） on the reducing toxicity in the normal and Heps-bearing mice in combination with ^60Co radiotherapy and Cy chemotherapy was analyzed, at the dose of 9, 3 and 1 mg/kg; And the promotion of YCP on the immune system in the tumor bearing mice was also studied. It is shownd that YCP（9, 3, 1 mg/kg）could significantly relieve the decrease of the number of the peripheral white blood cell, the number of bone marrow karyote and thymus index of normal mice hutted by Cy at a big dose（P〈0. 01,P〈0. 05）. And YCP（9, 3 mg/kg）could notably inhibited the decrease of the number of the peripheral white blood cell, the number of bone marrow karyote, spleen index and thymus index of tumor-bearing mice hurted by Cy at a big dose and ^60Co（P〈0. 01 ,P〈0. 05）. YCP（9, 3 mg/kg）could obviously increase the index of phagocytosis K and HC50 of tumor-bearing mice （P〈0.01, P〈0.05）. Therefore, YCP could significantly reduce the blood and bone marrow depression toxicity; and increase the immunological function of S180-bearing mice.