骨形态发生蛋白-7的研究进展

The Development of Bone Morphogenetic Protein-7 Research

骨形态发生蛋白-7(BMP-7)作为骨形态发生蛋白家族成员,能刺激未分化细胞定向分化为成骨细胞,调节骨发育,具有较强的骨诱导活性,能够在体内、体外诱导骨、软骨形成完成骨修复能力。BMP-7能完善移植骨的机械性能和功能,增强同种异体移植物的脊柱融合作用。除了在骨科中的应用外,BMP-7在口腔疾病和肾脏疾病中的应用日广。BMP-7在齿、牙槽骨的发育和重建中可发挥骨诱导作用,诱导牙髓牙本质的再生,从而减轻炎症反应。BMP-7在肾脏高度表达,能够保护肾小球完整性,具有抗肾脏纤维化作用。

As a member of Bone Morphogenetic Proteins family, BMP-7 can stimulate undifferentiation cell to differentiate osteoblast and adjust bone growth, and it has strong osteoinduction activity, BMP-7 can induce bone and cartilage formation in order to accomplish bone repair in vivo and in vitro. Moreover, it can improve the mechanism and function of bone implant and enhance allograft spinal fusion. Except for orthopaedics application, BMP-7 in stomatology and kidney disease application has become gradually a focal point. BMP-7 can induce endodontics, and dentinogenesis regeneration and relieve inflammation. BMP-7 high expression in kidney is capable of preserving glomerular intergrity and preventing renal fibrosis.