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负调节子SODD在TNFR-Ⅰ信号转导中的研究 被引量:3

The Advancement of Silencer of Death Domains as a Negative Regulatory Protein in TNF Receptor 1 Signaling
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摘要 SODD是一由457个氨基酸编码的分子量约为60kD的胞浆蛋白质,广泛表达于人类各组织细胞中,其作用主要是在TNFR-Ⅰ信号转导通路中充当负调节子,阻止TNFR-Ⅰ信号转导通路呈持续激活状态,以稳定内环境,维持正常生命过程。病理状态下,SODD过表达的组织细胞对细胞表面死亡受体介导的凋亡敏感性降低,对化疗药物表现出耐受性。
作者 陶红芳 胡群
出处 《中国肿瘤生物治疗杂志》 CAS CSCD 2005年第3期220-222,共3页 Chinese Journal of Cancer Biotherapy
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参考文献10

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  • 2陶红芳,胡群,张柳清,刘爱国,刘双又,胡迎.SODD和Bcl-2蛋白表达在儿童急性白血病中的意义及相关性探讨[J].中国肿瘤临床,2007,34(3):136-139. 被引量:5
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