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p53转录非依赖活性诱导细胞凋亡的研究进展 被引量：3

Mechanisms of Transcription-independent Apoptosis Triggered by p53
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摘要 p53主要有两条途径来介导细胞凋亡:通过促进下游促凋亡因子的基因转录来诱导凋亡;通过转录非依赖活性诱导细胞凋亡。研究发现在p53转录活性缺失,或者基因转录、蛋白翻译受抑制的情况下,p53仍然可以诱导细胞凋亡。研究结果提示p53的转录非依赖途径在促细胞凋亡中发挥着重要的甚至是关键的作用,所以对转录非依赖活性诱导细胞凋亡途径的深入了解将会对肿瘤治疗有所裨益。
作者 何伟刚 曹雪涛
机构地区 浙江大学免疫学研究所
出处 《中国肿瘤生物治疗杂志》 CAS CSCD 2005年第3期228-231,共4页 Chinese Journal of Cancer Biotherapy
关键词 P53 凋亡 转录非依赖 肿瘤治疗
分类号 R730.2 [医药卫生—肿瘤]
  • 相关文献

参考文献20

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共引文献13

同被引文献30

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引证文献3

二级引证文献2

中国肿瘤生物治疗杂志
2005年 第3期

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