硒的抗突变性作用与机体免疫功能的研究

Study on the Antimutagenic and the Immune Function of Selenium

研究了在三氯甲烷致突变性试验中加入硒的影响．结果显示硒能减少Ａｍｅｓ试验中三氯甲烷诱变的回变菌落数，能使小鼠骨髓嗜多染红细胞微核率和鳙鱼外周血有核红细胞微核率明显下降．并研究了硒在细胞免疫试验中的作用，结果显示硒能使正常鼠和荷瘤鼠的肺和脾的ＮＫ细胞活性提高，能促进其脾Ｔ淋巴细胞的增殖反应，还能增加外周血Ｔ淋巴细胞数．

Two aspects of the function of selenium were investigated' In the mutagenic tests. selenium diminished the number of reversed bacteria that trichloromethane induced in the Salmonella/Ames test and obviously .decreased the micronuclear rates of the polychromatoerythrocyte of bone marrow in mice and the peripheral blood erythrocytes of the variegated carp that had been induced by trichloromethane in micronuclears tests. In immune function tests. selenium increased the activity of natural killer cells in lung and spleen. increased the proliferation of spleen T lymphocytes and the number of peripheral blood T lymphocytes in the normal mice and tumor-bearing mice.