3-氨基-1H-1,2,4-三氮唑的合成工艺研究

Study on Synthesis Process of 3-Amino-1H-1,2,4-Triazole

以氨基胍碳酸盐和甲酸为原料,经成盐、酰化、环合反应得到3-氨基-1H-1,2,4-三氮唑。研究优化了反应时间、反应温度、共沸脱水体系以及产品精制溶剂等工艺条件,产品纯度达到99%,收率85%以上。

3-amino-1,2,4-Triazole was synthesized by salting out, acylation, and then cyclized action to obtain the product of 85.9% overall yield and 99.1% purity.