慢性牙周炎患者治疗前后血清CRP、sICAM-1水平的变化

Effects of Nonsurgical Periodontal Therapy on CRP and sICAM-1 Levels of Blood Serum with Chronic Periodontitis Patients.

目的:了解慢性牙周炎患者经过牙周非手术治疗前后血清C反应蛋白(c-reactive prote in,CRP)、可溶性细胞间黏附分子1(solub le intercellu lar adhesion molecu le-1,sICAM-1)的水平的变化。方法:选择22例中重度慢性牙周炎患者,治疗前后分别收集患者的血清,用酶联免疫吸附反应法(ELISA)方法测定CRP、sICAM-1水平,并和16例无其它系统疾病的临床牙周健康的对照组比较。结果:慢性牙周炎患者血清CRP、sICAM-1水平显著高于临床牙周健康的对照组。治疗后血清CRP、sICAM-1水平下降,接近牙周正常者水平。结论:慢性牙周炎影响血清CRP、sICAM-1的水平。牙周非手术治疗可以明显控制牙周局部炎症,降低血液中CRP、sICAM-1的水平。

Objectives： The aim of the present study was to determine whether the presence of chronic periodontitis and subsequent periodontal treatment could influence the serum levels of C - reactive protein （CRP） and soluble intercellular adhesion molecule - 1 （ sICAM - 1 ）. Methods ： Sera were obtained from 22 patients with moderate/severe chronic periodontitis at the baseline examination and at reassessment after non - surgical periodontal therapy. As a control, sera were also obtained from 16 subjects without periodontitis. CRP and sICAM - 1 were determined by sensitive enzyme - linked immunosorbent assay. Results： The levels of CRP and sICAM - 1 in the sera of chronic periodontitis were significantly higher than that in health control subjects. Periodontal status demonstrated a significant improvement in all patients following the treatment. CRP and sICAM - 1 concentration reduced significantly after the improvement of the periodontal condition following treatment and approached to that of control subjects. Conclusion ： In this study, we were able to show that periodontal disease significantly affected the serum levels of CRP and sICAM - 1.