静脉用丙种球蛋白联合红霉素治疗小儿毛细支气管炎30例

Combination of Gammavenin and erythromycin for treatment of 30 children with bronchiolitis

目的观察静脉用丙种球蛋白(IVIG)联合红霉素治疗小儿毛细支气管炎的疗效。方法60例毛细支气管炎患儿随机分两组,对照组30例给予抗感染及吸氧等常规治疗;治疗组30例在常规治疗的基础上加用静脉用IVIG(400 mg.kg-1.d-1)和红霉素针剂(30 mg.kg-1.d-1),疗程均为7 d;观察治疗前后患儿咳嗽、喘憋、呼吸困难、喘鸣音等症状和体征的消失时间及住院天数和疗效。结果治疗组患儿咳嗽、喘憋、呼吸困难、喘鸣音等消失天数明显短于对照组(P<0.05或P<0.01),住院天数无明显缩短(P>0.05);治疗组总有效率(96.7%)明显高于对照组(80%,P<0.05)。结论用IVIG和红霉素针剂可快速缓解毛细支气管炎患儿症状、体征,提高治愈率。

Objective To observe the clinical efficacy of combination of Gammavenin and erythromycin for treatment of children with bronchiolitis. Methods Sixty children with bronchiolitis were randomly divided into two groups： the anti-infections and oxygen therapy were performed in control group（30 cases） for seven days, Gammavenin （400 mg·kg^-1·d^-1） plus erythromycin（30 mg·kg^-1·d^-1）was performed in addition to conventional therapy for seven days. Extinction time of symptoms and signs of cough, wheeze, dyspnea and stridor, hospital day and efficacy were observed pre-and post-treatment. Results Extinction times of symptoms and signs of cough, wheeze, dyspnea and stridor in treatment group were obviously shorter than than in control group（P〈0.05 or P〈0.01）. Hospital day was not obvious shortness（P〉0.05）. Total effective rate in treatment group （96.7%）was obviously higher than that in control group（80%）（P〈0.05）. Conclusion Combination of Gammavenin and erythromycin for treatment of children with bronchiolitis can relieve quickly symptom and signs of bronchiolitis and improve cure rate.