高尿酸血症患者血脂紊乱的初步观察

Observation of dyslipidemia in patients with hyperuricemia

目的:观察和分析高尿酸血症患者血脂紊乱的特点。方法:对按不同糖耐量分组96例高尿酸血症患者临床资料进行统计学分析。结果:不同糖耐量的高尿酸血症患者,均伴有以高甘油三酯血症和低密度脂蛋白胆固醇(LDL-L)水平升高为主的血脂紊乱;随着各组血糖水平上升,有甘油三酯(TG)、LDL-L水平升高、高密度脂蛋白胆固醇(HDL-C)降低的趋势,高尿酸血症合并糖尿病组的TG高于正常血糖组,HDL-C低于正常血糖组,有统计学意义。各分组的尿酸值差异无统计学意义。结论:高尿酸血症患者存在以高甘油三酯血症和LDL-L水平升高为主的血脂紊乱,2型糖尿病合并高尿酸血症患者的脂代谢紊乱更严重,高尿酸血症与其所伴随的血脂紊乱是动脉粥样硬化、高血压、冠心病发病的共同危险因素。

Objective： To study the characteristics of dyslipidemia in patients with hyperuricemia. Methods： 96 patients with hyperuricemia were divided into three groups according to different glucose tolerance. The clinical data were analyzed. Results ： All the patients with hyperuricemia and different glucose tolerance had dyslipidemia mainly showing hypertriglyceridemia and rising of low-density lipoproteins （LDL-C） level. With the rising of concentration of blood sugar from normal glucose tolerance （IGT） group to type 2-diabetes （T2DM） group, the tendency of the rising of triglyceride（TG） level and LDL-C level, and the dropping in the level of high-density lipoproteins was found. The TG level was significantly higher in T2DM group than that in the IGT group,and the HDL-C level was remarkable lower than that in the IGT group. The uric acid level at three groups was not significantly different on statistics. Conclusion.. Patients with hyperuricemia have dyslipidemia mainly based on hypertriglyceridemia and rising of LDL-C level. The patients with hyperuricemia have the more serious metabolism disorder. Hyperuricemia and dyslipidemia that followed with are the common dangerous factors of the flaring up of atherosclerosis, hypertension and coronary heart disease.