支气管肺炎患儿血清6种细胞因子测定

Measurement of Serum Levels of Six Cytokines (IL-2, IL-5, IL-6, IL-10,TNF-α, IGF-Ⅱ) in Pediatric Patients with Bronchopneumonia

目的:探讨支气管肺炎患儿的发病与6种细胞因子的内在联系。方法:6种细胞因子的测定均采用放射免疫分析。结果:32例支气管肺炎患儿IL-2及IL-5水平显著高于对照组(P均<0.05);IL-6、TNF-α及IGF-Ⅱ水平较对照组均极显著升高(P均<0.01);IL-10则显著低于对照组(P<0.05)。结论:支气管肺炎患儿血清6种细胞因子均发生了显著变化,其水平的升高或降低与患儿肺部的炎症关系密切。

Objective To explore the role played by multiple cytokines in the pathogenesis of bronchopneumonia in pediatric patients. Methods Serum cytokines （IL -2,IL -5,IL -6,IL - 10,TNF - α,IGF - Ⅱ ） levels were determined with RIA in 32 pediatric patients with broncho-pneumonia and 35 controls. Results Serum IL-2,IL-5 （P〈O. 05） and IL-6,TNF-α,IGF- Ⅱ （P 〈0. O1 ） levels were significantly higher than those in the controls. However, serum IL - 10 levels were significantly lower in the patients than those in the controls （ P 〈 0.01 ）. Conclusion There were marked alteration of the serum levels of these cytokines in the bronchopneumonia patients, reflecting the complex immunoregulatory process following bacterial infection.