摘要
目的:探讨了2型糖尿病患者同型半胱氨酸(Homocysteine,Hcy)水平测定与血糖和胰岛素水平的相关性。方法:应用ELISA法测定66例2型糖尿病患者血Hcy水平,已糖激酶法测定血糖,放免法测定胰岛素含量并与35名正常健康人作比较。结果:2型糖尿病患者血Hcy水平非常显著的高于正常人组(P<0.01),与血糖和胰岛素水平呈明显的正相关(r=0.3515,0.3485,P<0.05)。结论:测定2型糖尿病患者Hcy水平对了解病情、观察疗效,是一个十分有用的检测指标,具有一定的临床价值。
Objective To explore the correlationship between plasma homocysteine and blood glucose, insulin levels in patients with type 2 diabetes mellitus. Methods Plasma homocysteine (with ELISA), blood glucose (with hexokinase method) and insulin (with RIA) levels were measured in 66 patients with type 2 diabetes mellitus as well as in 35 controls. Results Plasma homocysteine levels in the diabetic patients ( n = 66 ) were significandy higher than those in controls ( P 〈 0.01 ) , especially in those patients complicated with nephropathy (n = 32). The homocysteine levels were positively correlated with those of blood glucose and insulin (r = 0. 3515 ,r =0. 3486, both P 〈 0.01 ). Conclusion Plasma homocysteine is an independent risk factor for vascular diseases. The levels of plasma cysteine are significandy increased in patients with type 2 diabetes mellitus, especially in those complicated with nephropathy. Therefore, monitoring of plasma homocysteine level changes is clinically useful.
出处
《放射免疫学杂志》
CAS
2005年第5期338-339,共2页
Journal of Radioimmanology