2型糖尿病患者Hcy测定与血糖、胰岛素水平的相关性探讨

Investigation on the Correlationship Between Plasma Homo cysteine and BloodGlucose, Insulin Levels in Patients with Type 2 Diabetes Mellitus

目的:探讨了2型糖尿病患者同型半胱氨酸(Homocysteine,Hcy)水平测定与血糖和胰岛素水平的相关性。方法:应用ELISA法测定66例2型糖尿病患者血Hcy水平,已糖激酶法测定血糖,放免法测定胰岛素含量并与35名正常健康人作比较。结果:2型糖尿病患者血Hcy水平非常显著的高于正常人组(P<0.01),与血糖和胰岛素水平呈明显的正相关(r=0.3515,0.3485,P<0.05)。结论:测定2型糖尿病患者Hcy水平对了解病情、观察疗效,是一个十分有用的检测指标,具有一定的临床价值。

Objective To explore the correlationship between plasma homocysteine and blood glucose, insulin levels in patients with type 2 diabetes mellitus. Methods Plasma homocysteine （with ELISA）, blood glucose （with hexokinase method） and insulin （with RIA） levels were measured in 66 patients with type 2 diabetes mellitus as well as in 35 controls. Results Plasma homocysteine levels in the diabetic patients （ n = 66 ） were significandy higher than those in controls （ P 〈 0.01 ） , especially in those patients complicated with nephropathy （n = 32）. The homocysteine levels were positively correlated with those of blood glucose and insulin （r = 0. 3515 ,r =0. 3486, both P 〈 0.01 ）. Conclusion Plasma homocysteine is an independent risk factor for vascular diseases. The levels of plasma cysteine are significandy increased in patients with type 2 diabetes mellitus, especially in those complicated with nephropathy. Therefore, monitoring of plasma homocysteine level changes is clinically useful.