冠心病患者治疗前后血清SOD、ET及T淋巴细胞亚群水平

Clinical Significance of the Changes of Serum Levels of Superoxide Dismutase (SOD), Endothelin (ET) and T Cell Subsets Distribution Type After Treatment in Patients with Coronary Heart Disease

目的:探讨了冠心病患者治疗前后血清SOD、ET及T淋巴细胞亚群水平。方法:分别应用放免法和单克隆抗体法对42例冠心病患者进行了血清SOD、ET及T淋巴细胞亚群水平检测,并与35名正常健康人作比较。结果:冠心病患者在治疗前血清ET水平显著地高于正常人组(P<0.01),而SOD和CD4/CD8比值明显地低于正常人组(P<0.01),经治疗后一个月则与正常人组比较差异无显著性(P>0.05)。结论:检测冠心病患者血清SOD、ET及T淋巴细胞亚群水平对判断病情及其预后均具有一定的临床实用价值。

Objective To explore the changes in serum SOD, ET levels and T - lymphocyte subsets distribution type after treatment in patients with coronary heart disease. Methods The levels of serum SOD, ET were detected with RIA and T - lymphocyte subsets distribution type was detected with monoclonal antibody method in 42 cases of coronary heart disease both before and after a course of treatment and 35 controls. Results Before treatment, the levels of serum ET were significantly higher than those in controls （ P 〈0.01 ） , while the serum levels of SOD and CD4/CD8 ratio were significantly lower than those in controls （ P 〈 0. 01 ）. One month after treatment those variables were about the same in both groups （P 〉 0.05 ）. Conclusion Detection of serum SOD, ET and CD4/CD8 ratio is valuable for the diagnosis and outcome prediction in patients with coronary heart disease.