原发性高血压患者血浆血栓素B_2检测的临床意义

Clinical Significance of Determination of Plasma TXB_2 Contents in Patients with Essential Hypertension

目的:探讨原发性高血压(EH)患者的血浆血栓素B2(TXB2)水平的变化及阿司匹林对其的干预影响。方法:采用放射免疫分析测定105例EH患者、42例非高血压患者、15例EH患者给予阿司匹林干预治疗后的TXB2水平,进行对照统计分析。结果:EH组TXB2水平明显高于对照组,在性别之间则无显著性差异。经阿司匹林干预治疗后,EH组血浆TXB2水平显著下降。结论:检测TXB2对原发性高血压患者的诊断和治疗有重要的临床价值。

Objective To investigate the changes of plasma contents of TXB2 after aspirin treatment in patients with essential hypertension. Methods Plasma TXB2 contents were measured with RIA in 105 patients with essential hypertension and 42 controls. Fifteen patients were given aspirin 100mg/d × 15days and plasma TXB2 were measured again after completion of the treatment. Results Plasma TXB2 contents in patients with essential hypertension were significantly higher than those in controls （ P 〈 0. 01 ） with no sex differences. After a course of treatment with aspirin, the levels were significantly lowered （ vs before treatment, P 〈 0. 01 ）. Conclusion Hypercoagulability was present in patients with essential hypertension and could be corrected with aspirin treatment.