老年男性代谢综合征患者血浆ET-1和CGRP检测及意义

Clinical Significance of Determination of Changes of Plasma ET-1 and CGRP Contents in Elderly Males with Metabolic Syndrome

目的:探讨血浆内皮素(ET-1)和降钙素基因相关肽(CGRP)在老年男性代谢综合征患者中的变化特征及意义。方法:采用放射免疫分析对65例临床诊断为高血压、糖尿病和35例代谢综合征的老年男性患者进行血浆ET-1和CGRP的含量检测,同步检测血脂和血糖水平,以35例健康老年男性作为对照。结果:老年男性单纯高血压和糖尿病患者血浆ET-1水平明显增高,代谢综合征组ET-1水平亦明显增高,与对照组比较有显著性差异(P<0.01,P<0.05,P<0.01),高血压组ET-1水平明显高于糖尿病组(P<0.05)。高血压组与代谢综合征组CGRP水平均明显低于对照组,有显著性差异(P<0.05,P<0.05)。两组血浆ET-1水平增高与CGRP水平下降呈显著负相关(r=-0.75,P<0.01,r=-0.53,P<0.01)。结论:老年男性代谢综合征患者血浆中ET-1和CGRP表达异常及其关联在其发病过程中具有重要临床意义,其缩、舒血管作用失调参与了高血压和糖尿病发病的病理过程。

Objective To investigate the significance of changes of plasma endothelin - 1 （ ET - 1 ） and calcitonin gene related peptide （CGRP） contents in elderly males with metabolic syndrome, Methods Plasma ET - 1 and CGRP contents were measured with RIA in 65 elderly males with hypertension and 65 elderly males with diabetes. The blood lipid and sugar contents were measured simultaneously. 35 controls entered this study. Results The plasma ET - 1 contents in elderly males with simple hypertension, diabetes and metabolic syndrome were all significantly higher than those in controls （P 〈0. 01 ,P 〈0. 05 ,P 〈0. 05）. Levels in hypertensives were significandy higher than those in diabetics （P 〈 0. 05 ）. The plasma CGRP levels in the elderly males with hypertension and with metabolic syndrome were all significantly lower than those in controls （P 〈 0. 05, P 〈 0. 05 ）. The CGRP levels in these subjects were significantly negatively correlated with the ET - 1 levels （ r = - 0. 75, P 〈 0. 01 ; r = - 0. 53, P 〈 0.01 ）. Conclusion Changes of plasma ET - 1 and CGRP levels in elderly males with metabolic syndrome were clinically significant, especially in the pathogenesis of hypertension.