支气管肺炎患儿治疗前后血清SIL-2R和T淋巴细胞亚群的水平探讨

Study on the Changes of Serum Soluble IL-2 Receptor (SIL-2R) Levels and Distribution Pattern of Peripheral Blood T-cell Subsets After Treatment in Pediatric Patients with Bronchopneumonia

目的:探讨了血清可溶性白细胞介素-2受体(SIL-2R)和T淋巴细胞亚群水平在支气管肺炎患儿治疗前后的变化及意义。方法:应用双抗体夹心ELISA和单克隆抗体法对33例支气管肺炎病儿进行了治疗前后血清SIL-2R和T淋巴细胞亚群测定,并与30例正常儿作比较。结果:支气管肺炎病儿在治疗前血清SIL-2R水平显著地高于正常儿组(P<0.01)。治疗后2周血清SIL-2R水平与正常儿比较无显著性差异(P>0.05),SIL-2R与T淋巴细胞亚群中CD8细胞比值密切相关。结论:检测支气管肺炎病儿血清中SIL-2R和T淋巴细胞亚群水平可作为病情预后判断的重要指标。

Objective To investigate the significance of changes of serum SIL - 2R levels and T - cell subsets distribution type after treatment in podiatric patients with bomchopneumonia. Methods Serum SIL -2R levels （with ELISA） and peripheral blood T - cell subset distribution pattern （ with monoconal antibody technique） were determined in 33 podiatric patients with broncho - preumonia and 30 controls. Results Before treatment, the serum SIL - 2R levels in the patients were significantly higher than those in normal controls （P 〈 0.01 ）. After treatment for two weeks the SIL -2R levels in the two groups were about the same （P 〉 0.05 ）. Serum SIL - 2R levels were positively corrleated with CD4/CD8 ratio. Gonclusion Detect of serum SIL - 2R levels and CD4/CD8 ratio is clinically useful in the management of podiatric patients with bronchopneumonia.