利多卡因脂质体的初步研制及其质量评价

Preparation of Liposomal Lidocaine and It's Quality Evaluation

目的研制利多卡因的一种缓释长效制剂—利多卡因脂质体,并对其制备工艺进行研究,且评价其质量。方法以磷脂、胆固醇为膜材,采用乙醚注入法和薄膜分散法制备利多卡因脂质体并对制剂的形态学、载药量及包封率等进行研究。结果利多卡因脂质体为乳白色、近透明的胶体溶液。光镜下呈双同心球体满视野。测得其包封率分别为22.7%和21.6%,结论乙醚注入法和薄膜分散法两种制备工艺所得的利多卡因脂质体无明显区别。

Objective To prepare a sustained-release formulalion of lidocaine-liposomal lidocaine, study the formulation and preparation of liposonmal lidocaine, and evaluate its qualily. Methods Soy phosphalidylcholine and cholesterol were used as liposome malerials. Liposomes were prepared through ether injeetion method and film dispersion method. The morphology of liposomal lidocaine, the drug loading and the entrapment efficiency were studied. Results Liposomes were microscopie spheres that consis of a phospholipid bilaver that encapsulates an aqueous core. The pereentage of apparently entrapped lidocaine were 22.7% and 21.6% respectivcly. Conclusion There were no ohvious differences between liposomes prepared through the two methods.