北京地区45～74岁人群血清肌酐分布特征及其影响因素

The distribution of serum creatinine and its association with related factors in a population aged 45-74 in Beijing area

目的:描述北京地区45～74岁人群血清肌酐(sCr)水平及分布特点,分析sCr水平的影响因素。方法:1992年,对北京大学社区和首钢地区35～64岁人群,进行了基线心血管疾病(CVD)危险因素的调查。2002年对此人群(此时该人群年龄为45～74岁)进行了CVD危险因素的复查,并加入新的调查因素sCr,对复查结果进行统计分析。结果:1.sCr平均水平男性为1.09mgdL,女性为0.92mgdL,男性高于女性(P<0.001),sCr水平随着年龄的增长而升高(P<0.001)。在该人群中,肾功能损害的现患率为7.3%。2.血脂异常、超重、高血压、高血尿酸组和吸烟组的sCr水平高于正常组(P<0.05)。高血尿酸组,高血压组和高总胆固醇组肾功能损害的现患率高于正常组(P<0.001)。3.多因素分析显示,高总胆固醇、高血压、高血尿酸是肾功能损害的主要影响因素,它们的OR值分别为2.06、1.75和3.67(P≤0.001)。结论:北京地区45～74岁人群中sCr分布存在年龄和性别差异;sCr水平受血脂、血压、血尿酸、体质指数和吸烟等多种因素的影响,其中高总胆固醇、高血压和高血尿酸是肾功能损害的主要影响因素。

Objective-To describe the distribution of serum creatinine and analyze its association with related factors in a population aged 45-74 in Beijing area. Method： A baseline investigation on the risk factors of cardiovascular disease was carried out in a natural population of Beijing in 1992. A follow-up survey was conducted in the cohort in 2002, adding serum creatinine as a new ingredient. Result： 1. The average level of serum creatinine of males （1.09 mg/dL） was significantly higher than females （0.92 mg/dL） （P 〈 0.001 ）. And the level of serum creatinine showed trend of increasing with age （ P 〈 0.001 ）. The prevalence rate of renal dysfunction was 7.3% in this population. 2. Comparing with normal groups, the levels of serum creatinine were higher in groups of dyslipidemia, overweight, hypertension, hyperuricaemia and smoking （ P 〈 0.05 ）, and the prevalence rates of renal dysfunction were higher in groups of hypereholesterolaemia, hypertension and hyperuricaemia. 3. Hypercholesterolaemia, hypertension and hyperuricaemia were main influencing factors of renal dysfunction, with OR being 2.06, 1.74 and 3.67（ P 〈 0.001）.Conclusion：Gender, age, lipids, blood pressure, uric acid, body mess index and smoking exerted influence on serum creatinine level. Hypercholesterolaemia, hypertension and hyperuricaemia were main influencing factors of renal dysfunction.