共轭二炔结构类脂化合物的合成及其聚合脂质体的制备和稳定性研究

Synthesis of Diacetylenic Lipids and Studies on the Preparation and Stability of Polymerized Liposomes

合成了７种具有共轭二炔结构的单链类脂化合物，并将其分别制成聚合脂质体，考察了其在酸、碱、盐、缓冲液及乙醇等化学环境下的稳定性，结果表明二十五－１０，１２－二炔－１－醇磷脂乙醇胺的聚合脂质体稳定性最佳．

The seven lipids with diacetylenic structure were synthesized,using lipids Ⅰ-Ⅶ polymerized liposomes were prepared,and their stabilitics under different environmental conditions(e.g.,alcohol,acid,alkaline,salt and buffer solutions)were investigated. The results indicated that the polymerized liposome prepared with pentacosa-10, 12-diyne-1-olphosphoryl ethanolamine exhibited an enhanced stabilities.