胃肠道间质瘤的诊断和治疗:附32例报告

Diagnosis and treatment of gastrointestinal stromal tumors: a report of 32 cases

目的探讨胃肠道间质瘤的诊断和治疗方法。方法回顾性分析近5年间收治的3 2例胃肠道间质瘤的临床和病理资料。结果肿瘤多位于胃部,最多见的临床表现为腹部隐痛不适。手术前8 1.3%(2 6/3 2)的病例有不同程度的误诊。均行外科手术切除。其中因复发而2次手术者1 0例,3次及以上手术者8例。随访时间6个月至5年,死亡8例。结论胃肠道间质瘤容易误诊,其确诊主要依靠病理组织学检查及免疫组化染色。治疗以外科手术切除为主。复发的病例亦可反复手术而取得较为满意的效果。

Objective To explore the diagnosis and treatment of gastrointestinal stromal tumors （GISTs）. Methods Clinical and pathological data of the 32 GISTs cases treated over the recent 5 years in our hospital were reviewed retrospectively. Results Stomach was the most frequent site for GISTs. Abdominal pain was the most common symptom. Before operation, 81.3 % （26/32） of the cases were misdiagnosed. All of the cases underwent surgical resection. 10 recurrent GIST patients received a second resection, and 8 patients underwant three or more resections. Follow - up was made from six months to 5 years, and 8 patients died. Conclusions The diagnosis of GISTs is difficult and mainly depends on histopathology and immunohistochemistry. Surgical resection is the principal treatment of GISTs. Reoperation is effective for the treatment of recurrent cases.