清宫液Ⅱ号抗炎药理学研究

Study on anti-inflammatory effect of Qinggongye Ⅱ in vivo

为研究清宫液Ⅱ号的抗炎药理学作用,在实验室条件下建立了小鼠耳肿胀模型、毛细血管通透性增加模型、足跖肿胀模型和纸片肉芽肿模型等。结果表明,清宫液Ⅱ号对二甲苯引起的小鼠耳壳肿胀、醋酸引起的腹腔毛细血管通透性增加、角叉菜胶引起的足跖肿胀及前列腺素E2渗出、纸片引起的肉芽增生都具有明显的抑制作用,提示清宫液Ⅱ号具有良好的抗炎效果。

Mice auricle edema model,mice metatarsal swelling model,capillary osmosis model and granuloma model was made in order to study anti-inflammatory effect of Tinggongye Ⅱ.The results showed that Qinggongye Ⅱ could markedly inhibit xylene-induced swelling rate of mice auricle,acetic-acid-induced effusion of Evans Blue in abdomen,carrageeenan-induced mice metatarsal swelling rate,PGE2 quantity in inflammatory feet and paper-induced granuloma.It was suggested that Qinggongye Ⅱ has a definite anti-inflammatory effect.