6～13岁肥胖儿童血清瘦素与胰岛素、血脂的关系及意义

Relationship and Significance of Serum Leptin with Blood Insulin and Lipid in 6～13 Years Old Obese Children

为了探讨6～13岁儿童血中瘦素(Leptin)与体重指数(BMI)、胰岛素(INS)、甘油三酯(TG)、总胆固醇(TC)的关系及意义.对118名(男64名,女54名)6～13岁学龄期儿童(正常非肥胖儿童56名,肥胖或超体重儿童62例)血中Leptin进行测定,并与BMI、Insulin、TG和TC进行了相关性研究.结果显示:①肥胖或超体重儿童各项观察指标均明显高于非肥胖儿童(P＜0.001或P＜0.01);且两组同性别间均有肥胖或超体重儿童各项观察指标,均明显高于非肥胖儿童(P＜0.001或P＜0.05);②同组中男女间比较:两组均有女童Leptin值显著高于男童(P＜0.001或P＜0.05),BMI仅有肥胖或超体重组中女童显著高于男童(P＜0.001),各组中其余的观察指标均无明显差异(P＞0.05);③Leptin与BMI、Insulin和TG均存在明显正相关(P=0.001).表明Leptin 水平可随性别、BMI和血脂水平等因素作用而发生相应变化,如能研究和使用提高Leptin受体效应的药物,可能对防治肥胖有一定的帮助.

To explore relationship and significance of Serum Leptin with BMI, Insulin, triglyceride （TG） and total cholesterol （ TC ） in obese children aged 6- 13 years. Serum Leptin of school-age children 118 （64 male, 54 female ; normal non-obese 56 and obese 62 ） were determined and compared with BMI, Insulin,TG and TC . The results showed that ： ① Each index of obese children was remarkably higher than that of non-obese children （P〈0. 001 or P〈 0.01）, and each index between the same sex of the two groups of obese children was remarkably higher than that of non-obese children （P〈0. 001 or P〈0.05） . ② Comparason between the sex in the same group ： Lpetin level of female children was markedly higher than that of male（P〈0. 001 or P〈0.05 ） ; BMI of female children was markedly higher than that of males in obese group （P〈0.001）. The other indices were not different（P〈0.05 ） . ③ Leptin was poritinely corelation with BMI, insulin, TG and TC（P=0. 001 ）. Leptin level in serum may varied according to sex, BMI or blood lipid level . It is of great significance in prevention and treatment of obesity to use drug which may improve Leptin receptor effect .