缓释丙吡胺（异脉停）治疗心律失常疗效及安全性观察

Effect and Safety of Disopyramide-SR for the Treatment of Arrhythmias

目的：丙吡胺为Ｉａ类抗心律失常药，缓释丙吡胺为其长效剂型。本文旨在探讨该药的疗效和安全性。方法：采用随机分组自身单盲对照法对５８例室性和房性心律失常病人进行口服缓释丙吡胺（Ａ组３９例，０．５ｇ／日；Ｂ组１９例，０．２５ｇ／日）的临床研究。全部受试者在眼药前和眼药２周后行Ｈｏｌｔｅｒ、心电图等检查。结果：缓释丙吡胺治疗Ａ、Ｂ两组室性心律失常的有效率分别为８３％、７３％，治疗房性心律失常分别为８３％、７３％。服药后Ａ组病人的ＱＴｃ和ＪＴｃ间期分别延长９．３％和１０．９％（与治疗前比，Ｐ均＜０．００１），Ｂ组中ＱＴｃ和ＪＴｃ间期眼药前后无明显差异。该药非心脏方面的副作用主要有视觉障碍和排尿困难。结论：口服缓释丙吡胺对室性和房性心律失常均有效，并有长效、眼药方便、副作用较少等特点，可供临床进一步使用。

Objective: To investigate the effect and safety of disopyramide-SR, a Ia group anti-arrhythmic drug.Methods: By randomized single blind self-control,58 patients with atrial or ventricular arrhythmias were given disopyramide-SR orally (39 cases for group A, 0. 5g per day; 19 cases for group B, 0.25g per day). All of the cases were examined by Holter and ECG as well as other latoratory tests before and two weeks after the treatment. Results: The effectivities of disopyramide-SR for ventricular and atrial arrhythmias were 83% (10/12) and 83% (33/40), respectively in group A; 73% (8/11) and 73% (11/15), respectively in group B; QTc and JTc were prolonged by 9.3% and 10.9% (vs. pretreatment, all p<0.001), respectively in group A after treatment while there were no significant changes in group B. The main noncardiac side-effects were visual disturbance and urinary hesitancy.Conclusion: Oral. disopyramide-SR is an effective drug for ventricular or atrial arrhythmias,which bas the benefits of long effect, convenience to use, rare side-effect, etc. It is recommended to have further clinical use.