中西医结合治疗扩张型心肌病心衰临床研究

The Clinical Study on CHF in Patients with Dilated Cardiomyopathy Treated with Integrated Therapy of TCM and WM

目的观察中西医结合治疗扩张型心肌病(DCM)心衰(CHF)的临床疗效,并探讨其部分机制。方法将患者64例随机分为对照组与治疗组,两组均予西医常规处理,治疗组加用真武汤,并行心脏超声检查和TNF-α、HS-CRP测定。结果两组治疗后CO、LVEDd和LVEDs均有非常显著性改变;治疗组LVEF治疗后非常显著改善;CO治疗后治疗组较对照组有显著性增加。两组治疗后HS-CRP均有非常显著性改善;治疗组治疗后TNF-α有非常显著性改善;治疗后治疗组TNF-α较对照组有显著性改善,HS-CRP较对照组有非常显著性改善。结论中西医结合治疗DCMCHF具有确切疗效,其机制部分与抑制心肌炎症发展有关。

Objective:To observe the effect of congestive heart failure(CHF) in patients with dilated cardiomyopatyy(DCM)treated with Integrated Therapy of TCM and WM,and to seek for part mechanism.Methods:64 patients with DCM and CHF were randomly divided into the controlled group and the treatment group.All patients were treated with the usual therapy of WM,while those in the treatment group took Zhenwu Decoction, All pateints were examined with cardiac ultrasound,tumor necrosis factor-α (TNF-α)and high sensitive c- reactive protein(HS-CRP) were also assayed.Results:There were very significant difference of cardian output(CO),left ventricular end-diatolic diameter(LVEDd) and left ventricular end-systolic diameter(LVEDs)compared to pretreatment in both groups;left ventricular ejection fraction(LVEF)were very significantly improved after treatment in the treatment group,CO was significantly improved after treantment in the treatment group than in the control.There were very significant difference of HS-CRP compared to pretreatment in both groups;there were very significant difference of TNF-αcompared to pretreatment in the treatment group.TNF-α was significanlty improved after treatment in the treatment group than in the control,and HS-CRP was very significantly improved after treatment in the treatment group than in the control.Conclusion:There was firmly effect of DCM with CHF to treat with Integrated Therapy of TCM and WM,and the mechanism was partly related to inhibit the progression of cardiomyocyte inflammation.