垂体后叶素对内毒素休克兔的抗休克作用

The effect of pituitrin on rabbits with endotoxin shock

目的探讨垂体后叶素在内毒素休克中的抗休克作用。方法36只兔随机分为3组,每组12只,用注射大肠杆菌类毒素(LPS,0111B4)的方法制作内毒素休克兔模型。对照组(A组)不采取复苏措施;垂体后叶素组(B组)以垂体后叶素复苏;去甲肾上腺组(C组)以去甲肾上腺素复苏。监测血压、血气,测定血NO、CK-MB、ALT、AST、BUN、Cr。结果垂体后叶素除了收缩血管,升高血压的作用外,能抑制一氧化氮的生成,起到抗休克的作用,对心肌及肾功能的影响较去甲肾上腺素要小。结论垂体后叶素在感染性休克的治疗中具有较好的抗休克作用。

Objective To study the effect of pituitrin on rabbits with endotoxin shock. Methods Thirty six New Zealand rabbits were randomly divided into three groups with 12 rabbits each. Endotoxin shock was induced by intravenous injection of lipopolysaccharide（LPS, 0111B4 ）. Group A was not resuscitated by any medicine. Group B was resuscitated by pituitrin, and group C by noradrenalin. Blood pressure was monitored continuously. Blood gas and NO, CK-MB, ALT, AST, BUN, Cr were mensurated. Results Pituitrin inhibited the formation of NO, and had less influence on the function of the kidney and myocardial muscle than noradrenalin. Conclusion Pituitrin can be used in the therapy of endotoxin shock.