糖耐量受损人群动脉粥样硬化与炎症因子间关系的研究

A study on the relationship between atherosclerosis and inflammatory factors in subjects with impaired glucose tolerant

目的研究巨噬细胞移动抑制因子(MIF)、肿瘤坏死因子(TNFα)、C反应蛋白(CRP)在糖耐量受损(IGT)伴动脉粥样硬化(AS)中的作用。方法采用酶联免疫法或核素放免法检测IGT伴AS组、IGT不伴AS组和正常对照组血清MIF、TNFα和CRP的水平。应用超声检测颈动脉内膜中层厚度和动脉内径。结果IGT不伴AS组和IGT伴AS组的炎症因子水平高于正常对照组(P<0.05、P<0.01),IGT伴有AS的炎症因子的水平明显高于IGT不伴AS组(P<0.05)。炎症因子之间以及炎症因子与颈动脉内膜中层厚度、颈动脉的内径之间存在着明显的正相关。多元线性回归分析提示MIF和CRP可能是颈动脉内膜中层增厚的重要影响因素。结论炎症因子(MIF、TNFα、CRP)的过度表达可能参与了IGT和AS,这提示IGT和AS存在炎症状态。

Objective To study the relationship between atherosclerosis and inflammatory factors： Macrophage migration inhibitory factor（ MIF）, Tumor necrosis factor-α （TNF-α）, C-Reactive Protein （CRP） in subjects with impaired glucose tolerant. Methods The levels of plasma MIF, TNF-α, CRP in three groups （IGT without AS groups.IGT with AS groups and control groups） were examined by the method of ELISA and RIA. Ultrasound was applied to scan carotid arteries intimae-media thickness and arteries dilatation. Results The levels of inflammatory factors were shown higher in IGT without AS groups and IGT with AS groups than those of control groups （ P 〈 0. 05, P 〈0. 01 ）, the levels of inflammatory factors were shown higher in IGT with AS groups than those of IGT without AS groups （ P 〈 0. 05 ）. There was positive correlation among inflammatory factors , and there was also positive correlation between inflammatory factors and carotid arteries intimae-media thickness.arteries dilatation. Muhivariable analysis showed the importance factors of carotid arteries intimae-media thickness were MIF and CRP. Conclusion The levels of over expressed inflammatory factors（ MIF, TNF-α, CRP）in serum may take part in AS in subjets with impaired glucose tolerant. This means that it has inflammatory conditions in IGT and AS.