氯诺昔康与曲马多治疗骨折术后疼痛疗效的比较

Comparision of analgesia with lornoxicam versus tramadol in patients undergoing fracture surgery

目的比较氯诺昔康与曲马多在治疗骨折术后疼痛的疗效。方法采用随机、单盲和对照实验,将骨折术后疼痛患者155例随机分为治疗组77例,对照组78例。治疗组给予氯诺昔康16mg肌注,对照组给予曲马多100mg肌注,采用感觉模拟评分法(VAS)对给药8h内疗效进行评估,并比较其不良反应的发生率。结果给药8h内治疗组疼痛缓解程度优于对照组(P<0.05),不良反应发生率分别为3.90%,12.82%(P<0.05)。结论氯诺昔康治疗骨折术后疼痛与曲马多相比较疗效更好,不良反应更少,可作为术后镇痛的一种新型高效药物。

[Objective] To compare the effectiveness of lomoxicam and tramadol on the pain after fractural operation. [Methods] This study was carried out in a randomized single-bhnd control test with 155 patients divided into two groups undergoing fractural operations. Experimental group （77 patients） was administered 16 mg of lornoxicam im. Control group （78 patients） was administered 100 mg of tramadol. Pain was assessed by patients using visual analog scales （VAS） at 1, 2, 4, 6 and 8 hours after using drugs and rate of adverse event was also evaluated. [ Resuits] Lornoxicam had greater analgesic efficacy than tramadol in patients （P 〈0.05）, and caused fewer adverse events than tramadol （3.90% vs 12.82%, P 〈0.05）. [Conclusion] Lomoxicam has more significant analgesic efficacy and fewer adverse events than tramadol after fracture surgery, It suggests that lornoxicam provides a new effective analgesic.