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β-分泌酶——治疗阿尔茨海默病的靶点 被引量：2

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作者 董炜疆 冯改丰
机构地区 西安交通大学医学院人体解剖与组织胚胎学系
出处 《医学综述》 2005年第10期865-867,共3页 Medical Recapitulate
基金 国家自然科学基金资助(C030313) 国家自然科学基金资助(C030316)
关键词 阿尔茨海默病 Β-分泌酶 抑制剂 Β-淀粉样肽
分类号 R749.16 [医药卫生—神经病学与精神病学] Q71 [生物学—分子生物学]
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参考文献18

  • 1陈生弟.神经病学:神经变性性疾病[M] 第18卷[M].北京:人民军医出版社,2002.262269.
  • 2Evin G, Weidemarm A. Biogenesis and metabolism of Alzheimer's 3disease Aβ amyloid peptides [J]. Pe ptides, 2002,23 ( 7 ) : 1285-1297.
  • 3Huntington P, lnge MW, Lars NN. The inflammation induced pathological chaperones ACT and Apo-E are necessary catalysts of Alzheimer amvloid formation [J]. Neurobiol Aging, 2001,22 (6) : 923-930.
  • 4Yan R,Bienkowski MJ, Shuck ME, et al. Membrane-anchored aspartyl protease with Alzheimer' s disease beta-secretase activity [J]. Nature,1999,402(6761) :533-537.
  • 5Yan R, Bienkowski MJ, Shuck ME, et al. BACE2 functions as an alternative secretase in cells[J]. J Biol Chem, 2001,276(36) : 34019-34027.
  • 6Farzan M, Schnitzler CE, Vasilieva N. BACE2, a beta-secretase homolog, cleaves at the beta site and within the amyloid-beta region of the amyloid-beta precursor protein[J]. Proc Natl Acad Sci USA, 2000,97(17):9712-9717.
  • 7Vassar R, Bennett BD, Babu-Khan S, et al. β-sccretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE[J]. Science, 1999,286(5440):735-741.
  • 8Zhao J, Paganini L, Gordon M, et al. Beta-secretase processing of the beta-amyloid precursor protein in transgenic mice is efficient in neurons but inefficient in astrocytes [J] .J Biol Chem, 1996,271 (49):31407-31411.
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同被引文献38

  • 1杨红旗,陈生弟.α分泌酶在阿尔茨海默病治疗中的作用[J].生物化学与生物物理进展,2006,33(2):109-115. 被引量：18
  • 2鄢浩,姜凤超.γ-分泌酶抑制剂研究进展[J].化学进展,2006,18(2):355-362. 被引量：7
  • 3鄢浩,姜凤超.γ-分泌酶抑制剂的药效团模型构建[J].物理化学学报,2006,22(3):359-364. 被引量：6
  • 4Wirths O, Multhaup G, Bayer T A. A modified beta-amyloid hypothesis: intraneuronal accumulation of the beta-amyloid peptide-the first step of a fatal cascade [J]. J Neurochem, 2004,91(3):513-520.
  • 5Roherds S L, Anderson J, Basi G, et al. BACE knockout mice are healthy despite lacking the primary beta secretase activity in brain:implications for Alzheimer's disease therapeutics [J]. Hum Mol Genet, 2001,10(12) : 1317-1324.
  • 6Zohar O, Cavallaro S, D'Agata V, et al. Quantification and distribution of beta secretase alternative splice variants in the rat and human brain [J]. Mol Brain Res, 2003,115 : 63-68.
  • 7Kuramer C, Wehner S, Quast T, et al. Expression and potential function of beta-amyloid precursor proteins during cutalleous wound repair [J]. Exp Cell Res, 2002,280(2) : 222-232.
  • 8陈生弟.神经病学[M].第18卷.北京:人民军医出版社,2002:262-269.
  • 9Yang F, Lim G P, Begum A N, et al. Curcumin inhibits formation of amyloid beta oligomers and fibrils, binds plaques, and reduces amyloid in vivo [J]. J Biol Chem, 2005,280(7):5892-5901.
  • 10Siman R, Velji J. Subunit composition of γ-secretase and effect of mutant presenilin-1 [J]. Neurobiol Aging, 2002,25(1) : 177-181.

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医学综述
2005年 第10期

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