子宫内膜增生与内膜癌增殖细胞核抗原表达

Relationship between Endometrial Hyperplasia and Expression of Nucleus Antigen in Carcinoma of Endometrium

目的探讨子宫内膜增生与内膜癌增殖细胞核抗原表达计数相关性,及其对判断生物学行为及预后的意义。方法应用抗增殖细胞核抗原(PCNA)的单克降抗体,以ABC免疫组织化学方法对144例子宫内膜标本进行测定,并与病理学诊断进行对比分析。结果在各种类型子宫内膜中PCNA的表达计数,依病变的进展明显递增,子宫内膜癌组PCNA表达计数明显高于正常子宫内膜组及子宫内膜增生组(增殖期除外),各组相比较有差异显著性(P<0.01)。结论ABC免疫组织化学法是测定子宫内膜增生细胞增值分数的有效手段。

Objective To study the relationship between endometrial hyperplasia and the expression of proliferative cell antigen in carcinoma of endometrium and its characteristic. Methods 144 endometrial and compareized with diagnosis of pathology by PCNA and ABC immunotissue chemistry. Results With progression of lesion, the expression of PCNA in endometrium decreased. The level of PCNA in carcinoma of endometrium was obviously higher than that of normal control and general endometrium（ P 〈0.01）. Conclusion ABC immumotissue chemistry is efficient to evaluate the duplication of endometrium and is very important to value its function and prognosis and can be one of differential diagnosis indexes on malignant and benign endometrium.