原发性骨质疏松症患者骨密度和骨代谢指标的对比研究

A comparative study of bone mineral density and bone metabolic markers in primary osteoporosis

目的探讨骨密度(BMD)和骨代谢指标在原发性骨质疏松症的诊治过程中的临床意义。方法采用XR36型双能X线骨密度仪和放射免疫方法,对252例中老年志愿者不同部位的BMD及血清骨钙素(BGP)、Ⅰ型前胶原氨基端前肽、Ⅰ型胶原交联羧基末端肽的含量进行测定。结果①无论是对照组还是骨质疏松组(OP),老年男性BMD均明显高于老年女性BMD,其差异具有非常显著性(P<0.01);②OP组的BGP值明显低于对照组,其差异具有显著性(P<0.05);OP组的血清Ⅰ型前胶原氨基端前肽(PINP)值均明显低于对照组,而血清Ⅰ型胶原交联羧基末端肽(ICTP)值均明显高于对照组,其差异具有显著性(P<0.05)。结论联合检测BGP、PINP和ICTP水平可直接反映骨胶原合成和降解状态,对于判断老年OP的进程以及指导OP的用药有着重要的意义。

Objective To explore the clinical significance of bone mineral density （BMD） and bone metabolic markers in the diagnosis and treatment of primary osteoporosis. Methods BMD at various skeletal sites was measured by XR-36 dual energy X-ray absorptiometry for 252 mlddle-and older aged voluteers, and their serum levels of BGP,PINP and ICTP were determined by radioimmunoassay. Results （1） Significantly higher BMD was shown in male subjects（ P 〈 0.01）. （2） The levels of serum BGP and PINP in OP group were lower than that in control group,whereas the level of ICTP was statistically higher than that in control group（ P 〈 0.05）. Conclusions The combined determinations of BMD and serum BGP, PINP,ICTP reflect bone collagen metabolic status,which is of important significance for the diagnosis and treatment of primary osteoporosis.