DXA测定诊断骨质疏松症的敏感指标

Sensitive index for diagnosing osteoporosis by DXA

目的探索双能X线吸收法(DXA)骨密度测定仪测定诊断骨质疏松症(OP)的敏感指标。方法随机抽取成都地区年龄20岁以上健康男、女1456名(其中女性793名),准确测定身高(H)、体重(W)后,采用美国Lunar公司生产DPXL型DXA测定受试者腰椎和髋部的骨矿含量(BMC)、骨密度(BMD)。全部资料输入微机,用SPSS软件进行统计学处理。结果男、女在峰值骨量后,随年龄增加,BMC、BMCW、BMD均逐渐下降,BMC、BMD、BMCW累积丢失率在40岁以上组均随年龄增加而增加,女性丢失更明显(P<0.05),同部位、同年龄组三指标累积丢失率差异无显著性(P>0.05)。OP检出率以BMD为参照指标最高,明显高于BMCW、BMC二指标(P<0.05)。结论DXA测定中BMD能较好反应BMC、BMCW变化,是诊断OP的敏感指标。

Objective To oxpiore the sensitive index for diagnosing osteoporosis by DXA. Methods A total of 1456 healthy subjects aged 20 and over, wore randomly recruited for measure ment of their heights and weights, and their BMC, BMD in lumbar vertebrae and hip boue by DXA. All data were analyzed. Results BMC, ratio of BMC to weight （BMC/W）, and BMD decreased with increasing age. The rate of accumulative loss of BMC, BMD and BMC/W in the gorup aged 40 and over increased with increasing age, especially for females. There were no significant differences in the rate of accumulative loss of among these three indexes （ P 〉 0.05）. The detectable rate of osteoporosis for BMD was higher than those for the other two indices with significant differences （P 〈 0.05 ）. Conclnsions BMD reflects the changes in BMC and BMC/W using DXA;It is a sensitive index for diagnosing osteoporosis.