氨基磺酸催化合成4-苯基-6-甲基-5-乙氧羰基-3,4-二氢嘧啶-2(H)-酮

Synthesis of 4-Phenyl-6-methyl-5-ethoxycarbonyl-3,4- dihydropyrimidin-2(H)-one Catalyzed by Sulfamic Acid

以氨基磺酸为催化剂,无水乙醇为溶剂,苯甲醛、乙酰乙酸乙酯、尿素为原料,合成了4-苯基-6-甲基-5-乙氧羰基-3,4-二氢嘧啶-2(H)-酮。研究了反应条件对产物收率的影响,确定了最优合成工艺条件:尿素为37·5mmol时,n(苯甲醛)∶n(乙酰乙酸乙酯)∶n(尿素)=1·0∶1·2∶1·5,催化剂氨基磺酸用量0·6g,反应温度60℃,反应时间45min。在此条件下,产物收率为91·2%。

4- Phenyl - 6 - methyl - 5 - ethoxycarbonyl - 3,4 - dihydropyrimidin - 2（H） - one was synthesized from benzaldehyde, ethyl acetoacetate, and urea using sulfamic acid as catalyst and anhydrous ethanol as solvent. The effects of reaction conditions on the yield of the product were investigated and the optimum conditions were determined as follows ： n （benzaldehyde） ic acid 0. 6 g, reaction temperature above conditions. ： n（ethyl acetoacetate） ： n （urea 37.5 mmol） = 1.0： 1.2： 1.5, amount of sulfamic acid 0.6 g,reaction temperature 60 ℃ ,reaction time 45 min. The yield of the product was up to 91.2% under above conditions.