吉西他滨联合奥沙利铂治疗晚期胰腺癌

Treatment of Advanced Pancreatic Cancer with Combination of Gemcitabine and Oxaliplatin

目的评价吉西他滨联合奥沙利铂治疗晚期胰腺癌的疗效.方法用吉西他滨1 000 mg/m2+5%GS 250 mL,ivgtt 30 min d1,d8;奥沙利铂130 mg/m2+5%GS 500 mL,ivgtt 2 h d1.每3～4周重复用药.治疗晚期胰腺癌21例.结果可评价16例,完全缓解0例、部分缓解2例、稳定8例、进展6例,有效率为12.5%.毒副反应能够耐受.结论吉西他滨联合奥沙利铂治疗晚期胰腺癌具有一定疗效,且毒副反应低.

Objective To evaluate the efficacy and safety of gemcitabine and oxaliplatin in the patients with advanced pancreatic cancer. Methods Twenty-one patients were enrolled. The treatment consisted of gemcitabine 1000 mg/m^2 （30 minute infusion）on day 1 and 8 and oxaliplatin 130 mg/m^2 （2 hour infusion）on day 1 every 3-4 weeks. Results Sixteen patients were evaluable. Complete response was observed in 0 patient. Partial responses were observed in 2 patients, stable disease in 8 and progress disease in 6. The overall response was 12.5%. The Treatment was well tolerated. Conclusion Gemcitabine and oxaliplatin showed encouraging activity in the patients with advanced pancreatic cancer.