致细菌性阴道病凝固酶阴性葡萄球菌的耐药性现状分析

ANTIBOTIC RESISTANCE ANALYSIS FOR COAGULASE-NEGATIVE STAPHYLOCCI WHICH INCUBATED BACTERIAL VAGINOSIS

目的研究凝固酶阴性葡萄球菌(CNS)的耐药性及其与细菌性阴道病的关系。方法常规培养细菌性阴道病患者的阴道分泌物,应用微生物分析系统MicroScan AutoScan-4进行鉴定及配套PC12板进行药敏试验。结果134例CNS中,耐药率在50%以上的抗生素有氨苄西林、环丙沙星、庆大霉素、红霉素、青霉素、四环素、诺氟沙星、苯唑西林等8种,其中氨苄西林、青霉素、苯唑西林等3种抗生素的耐药率高达90%以上,分别为93.3%、92.5%和94.0%;仅对万古霉素、阿莫西林/克拉维酸保持敏感,耐药率在10%以下,分别为9.2%和4.5%,而51例金黄色葡萄球菌的耐药性与之相比,无显著性差异(P>0.05)。结论CNS耐药性的改变,可能为其致细菌性阴道病的原因之一。

Objective To study the antibiotic resistance of Coagulase-Negative Staphylococci and its relation with bacterial vaginosis. Methods The secretion of bacterial vaginosis was cultured regularly, and the sensitivity of CNS to 18 antibiotics were tested by the Microscan AutoScan-4. Results In the 134 CNS, the resistances of ampiciUin, ciprofloxacin, gentamicin, erythromycin, penicillin, tetracycoine, norfloxacin, ocacillin were all above 50%, only susciptiahie to vancomycin and amoxicitliin/clavulanic acid, and there was not diffenence in the resistance rate between Styphylococcus aureus.