摘要
目的观察大鼠海马快速电点燃模型海马结构的可塑性改变,探讨其与癫痫发作的关系。方法24只Wistar大鼠右侧海马植入双极电极,平分为2组:对照组和电刺激组,观察动物发作行为,记录脑电发放,行右侧海马部尼氏体、胶质纤维酸性蛋白(GFAP)和脑源性神经营养因子(BDNF)染色。结果与对照组相比,癫痫发作组出现明显的神经元缺失、胶质细胞增生和BDNF表达上调。结论本模型中海马结构的可塑性改变可促进癫痫发作,是慢性癫痫得以维持和发展的结构基础。
Objective To assess the plasticity of hippocampus in hippocampal kindled rats and explore the relation between it and epilepsy. Methods Bipolar electrodes were implanted in the right hippocampus of 24 Wistar rats, half of which were electrically stimulated and the other half as controls. Their behaviors and EEG were observed, while the pathological sections including Nissl body, GFAP and BDNF were stained. Results Statistically the differences were significant in view of neuron deletion, glia hyperplasia and the express of BDNF between two groups. Conclusion The change in plasticity of hippocampus can facilitate seizure and structurally, it supports the maintenance and even development of chronic epilepsy.
出处
《中华神经医学杂志》
CAS
CSCD
2005年第10期983-986,共4页
Chinese Journal of Neuromedicine
基金
广东省自然科学基金重点项目(20013110)
关键词
电点燃
海马
可塑性
Electrical kindling
Hippocampus
Plasticity
