核苷酸类逆转录酶抑制剂的进展与评价

Evaluation and Research Development of Nucleotide Reverse Transcriptase Inhibitor in the Patients with HIV Virus Infection

目的:回顾核苷酸类逆转录酶抑制剂的研究进展,并评价其临床疗效和安全性,以期为临床合理用药提供参考。方法:采用近期国内、外文献综述方法。结果与结论:自20世纪60年代相继发现了病毒的逆转录酶、蛋白酶、整合酶,启迪着医药学者为对抗病毒而择选新的切入靶位,也标志着药物联合治疗(鸡尾酒疗法)治疗获得性免疫缺乏综合征(艾滋病)的开始。逆转录酶抑制剂可抑制人体免疫缺陷病毒的感染,为治疗获得性免疫缺乏综合征提供了全新效果,受得临床医师和患者的青睐,成为维系艾滋病患者生命的纽带。

OBJECTIVE：To review study progress of nucleotide reverse transcriptase inhibitors（NRTI） and evaluate their clinical efficiency and the safety, in order to provide some references for rational drug use in the clinic. METHODS： By collecting and reviewing the literatures at home and abroad. RESULTS ＆ CONCLUSION：Discovery of reverse transcriptase, protease and integrase was a breakthrough in drug research in the 60s of 20th century, which started combined drug therapy （cocktail therapy） for AIDS. NRTI can inhibit infection of human immunodeficiency virus（HIV） and give perfect results, so they have earned patients＇ commendation. With the development of the society, NRTI have already become the vincula for maintaining the lives of the patients with AIDS.