摘要
目的:在严格的质量评价基础上,对丁咯地尔治疗急性脑梗死的临床疗效与安全性进行系统评价.方法:全面收集丁咯地尔治疗急性脑梗死的临床试验,应用固定效应模型的Meta分析对7项研究结果进行同质性检验和合并效应量的估计,用漏斗图分析发表性差异.结果:同质性检验:X2=5.821,自由度为6,P＞0.05;合并效应值的估计:0R合并=2.51,0R合并95%可信区间为1.615～3.899;0R合并的检验:X2=16.528,P＜0.01.个别有轻度面红、恶心等不良反应少,漏斗图提示存在发表性偏倚.结论:丁咯地尔治疗急性脑梗死有确切疗效,且安全、不良反应少,但尚需进行严格的、多中心的随机双盲对照试验,以提供更有效说服力的证据.
OBJECTIVE ： On the basis of strict quality evaluation, clinical curative effect and the safety of buflomedil for the treatment of acute cerebral infarction （ACI） were made a system evaluation. METHODS： By overally collecting clinical trials of buflomedil for the treatment of ACI, using meta analysis of fixed effect model to make an estimation of homogeneity test and overall effect for 7 research findings, and analyzing publication difference with funnel figure. RESULTS： Homogeneity test： X^2 = 5.821, D/F was 6, P 〉 0.05; Estimation of merging effect value： OR merging = 2.51, OR merging 95% confidence interval was： 1.615 -3.899; OR merging test： X^2 = 16.528, P 〈 0.01. Individual patient had slight flushing, adverse effect like nausea was less, funnel figure showed there existed publication bias. CONCLUSION： Buflomedil has confirmative curative effect on the treatment of ACI. It is safe and has less adverse effect. However, there still need some strict and muhicentric randomized double - blind control tests to be carried out, in order to provide more effective and convinced evidence .
出处
《中国医院用药评价与分析》
2005年第5期289-291,共3页
Evaluation and Analysis of Drug-use in Hospitals of China
