多西紫杉醇与顺铂联合化疗治疗非小细胞肺癌

Chemotherapy with Docetaxel and Cisplatin in Non-small-cell Lung Cancer

目的:多西紫杉醇与顺铂联合化疗治疗非小细胞肺癌的疗效及副反应.方法:我院2002年10月至2004年2月确诊的Ⅲ～Ⅳ期非小细胞肺癌45例,分成治疗组25例(多西紫杉醇75mg/m2静脉滴注,d1,顺铂75mg/m2静脉滴注,d1,21d一周期);对照组20例(盖诺25mg/m2,d1、d8,静脉滴注,顺铂80mg/m2,d1静脉滴注,21d一周期).结果:治疗组总有效率72%,对照组总有效率40%,两组有显著性差异.静脉炎发生率对照组明显高于治疗组.结论:多西紫杉醇与顺铂联合化疗治疗非小细胞肺癌是安全有效的.

The peripheral phlebitis was more pronounced in control group （P〈0.05）. Conclusions： Compared with the control group, the regimen of docetaxel and cisplatin was effective and safe for patients with non-small-cell lung cancer.