摘要
目的:研究黄芪总黄酮提取物对维甲酸造成的大鼠骨质疏松状态的改善作用。方法:大鼠口服维甲酸80 mg·kg-1· d-1,连续2周后造成骨质疏松模型,观察黄芪总黄酮提取物的药理作用。结果:与维甲酸模型组比较,黄芪总黄酮提取物的中、高剂量组能显著提高骨质疏松模型大鼠的骨密度,并且对大鼠的骨长度指数、体重及生殖器官脏器指数也有一定的影响。结论:一定剂量的黄芪总黄酮提取物有明显的改善骨质,增加骨密度、防治生殖器官损伤的作用。
Objective： To study and analyze the effects of total flavone of astragalus extract （TFA） on osteoporotic rats caused by retinoic acid. Method： Osteoporosis was induced by retinoic acid （80 mg· kg^-1, P. O. ） daily in rats for two weeks. The pharmacological effects of TFA extract were observed. Result： Compared with the retinoic acid model group, TFA of median and high dosage group could significantly increase the bone density of the osteoporotic rats. Moreover, it had definite effects on bone length index, body weight, reproductive organs and viscera index of osteoporosis model rats. Conclusion： TFA may ameliorate the bone quality, enhance the bone density, prevent and cure the injury of reproductive organ in osteoporosis model rats.
出处
《中国药师》
CAS
2005年第11期895-897,共3页
China Pharmacist
基金
湖北省卫生厅项目"中药黄芪防治骨质疏松症活性部位的研究"(2001-2004)
关键词
黄芪总黄酮提取物
维甲酸
骨质疏松
Total flavone of astragalus extract （TFA）
Retinoic acid
Osteoporosis
