糖适平与胰岛素联合治疗磺脲药失效2型糖尿病的临床疗效

Study on Clinical Effects of Insulin Combined with Glurenorm on Treating Type Ⅱ Diabetes with Sulfonylurea Failure

目的:将糖适平与中效胰岛素联合应用于继发性磺脲药失效的2型糖尿病患者,以探讨其临床应用价值。方法:40 例入院诊断为磺脲药继发性失效的2型糖尿病患者,先予早晚注射中效胰岛素治疗,对其中30例空腹血糖(FBG)<7．8 mmol ·L-1,餐后2h血糖仍大于11．1 mmol·L-1的患者,给予3餐前口服糖适平,观察餐后血糖变化。结果:经糖适平治疗,平均餐后血耱(PBG)由13．6±2．6 mmol·L-1降至7．2±3．7 mmol·L-1,有统计学差异。结论:对磺脲药失效患者采用中效胰岛素与糖适平联合应用,可使空腹及餐后血糖得到良好控制。

Objective： To study the clinical effects of insulin combined with glurenorm on treating type Ⅱ diabetes with sulfonylurea failure. Method： 40 patients of type Ⅱ diabetes with sulfonylurea failure were given insulin injection at morning and bedtime. 30 cases whose fasting blood glucose （FBG） was smaller than 7.8 mmol·L^-1 and postprandial blood glucose （PBG） was bigger than 11.1 mmol· L^- 1. After insulin injection were given pre-prandial glurenorm orally tid. The changes of postprandial blood glucose were recorded. Result： The mean PBG was decreased from 13.6：1：2.6 mmol · L^-1 to 7.2±3. 7 mmol·L^-1 after glurenorm therapy. The decline had statistical significance. Conclusion： The administration of insulin combined with glurenorm can control the PBG on patients of type Ⅱ diabetes with sulfonylurea failure,