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凋亡抑制因子survivin在肝癌中的表达和意义及其与c-myc的相关性 被引量：1

EXPRESSION AND IMPLICATION OF survivin AND ITS CORRELATION WITH c-myc IN HEPATOCELLULAR CARCINOMA
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摘要 目的检测肝细胞癌中凋亡抑制因子survivin的表达,研究其与肝癌临床病理特征的关系;同时研究survivin与原癌基因c-myc表达的相关性。方法采用免疫组织化学技术和Western Blotting技术,检测59例肝癌组织及癌旁非癌组织中survivin和c-myc蛋白的表达。结果59例肝癌组织中36例表达survivin蛋白,其中29例c-myc表达阳性,7例c-myc表达呈阴性或弱阳性;23例不表达survivin蛋白或弱阳性表达者,c-myc的表达5例阳性,18例阴性或弱阳性,而在癌旁非癌组织中未检测到survivin蛋白的表达。survivin的表达与HCC镜下门静脉癌栓及局部肿瘤复发密切相关(P<0.05),而与肿瘤大小,肿瘤包膜,肝硬化及病理分期无关(P>0.05)。HCC中survivin和c-myc表达呈明显正相关(P<0.05)。结论survivin在肝细胞癌中通过加强c-myc的功能促进肝癌的发生发展,survivin有望成为HCC诊断和治疗的新靶点。 Objective To investigate the expression of survivin and its relationship with the clinicopathologic feature of hepatocellular carcinoma （HCC）, and the correlation between the expression of survivin and c-myc. Methods In 59 specimens of HCC tissues and non-cancerous adjacent liver tissues, the expression of survivin and c-myc was detected by using immunhischemistry and Western-blotting. Results Of the 36 （61.0%） cases of HCC expression survivin in 59 cases of HCC, 29 were positive for the expression of c-myc and 7 were slightly positive or negative; of the 23 cases without expressing survivin or slightly positive, 5 cases were positive for c-myc and 18 negative or slightly positive. Survivin was not detected in non-cancerous adjacent liver tissues. The expression of survivin in HCC had no association with tumor size, capsule status, the classification of cirrhosis and TNM stage （P 〉 0.05）, but with portal vein tumor thrombus and local recurrence （P 〈0.05）. The expression of survivin was significantly correlated with the expression of c-myc in HCC （P 〈 0.05）. Conclusion Survivin probably promotes the metastasis of HCC by enhancing the function of c-mvc, and survivin could be a new diagnostic/therapeutic target in HCC.
作者 王少军 张峰 邹奇飞 姜超
机构地区 南京医科大学第一附属医院肝脏外科
出处 《实用临床医药杂志》 CAS 2005年第9期75-78,共4页 Journal of Clinical Medicine in Practice
基金 江苏省医学135人才基金(135-43)
关键词 SURVIVIN C-MYC 肝细胞 癌 survivin c-myc carcinoma hepatocellular
分类号 R735.7 [医药卫生—肿瘤]
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参考文献16

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二级参考文献24

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共引文献26

同被引文献12

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实用临床医药杂志
2005年 第9期

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