1[17]Xiao RP, Ji X, Lakatta EG. Functional coupling of the β2-adrenoceptor to a pertussis toxin-sensitive G protein in cardiac myocytes. Mol Pharmacol 1995; 47:322-329.
2[18]Xiao RP, Avdonin P, Zhou YY, Cheng H, Akhter SA,Eschenhagen T, Lefkowitz RJ, Koch WJ, Lakatta EG. Coupling of β2-adrenoceptor to Gi proteins and its physiological relevance in murine cardiac myocytes. Circ Res 1999; 84:43-52.
3[19]Kilts JD, Gerhardt MA, Richardson MD, Sreeram G, Mackensen GB, Grocott HP, White WD, Davis RD, Newman MF, Reves JG, Schwinn DA, Kwatra MM. β2-adrenergic and several other G protein-coupled receptors in human atrial membranes activate both Gs and Gi. Circ Res 2000; 87:705-709.
4[20]Xiao RP, Tomhave ED, Wang DJ, Ji X, Boluyt MO, Cheng H, Lakatta EG, Koch WJ. Age-associated reductions in cardiac β1- and β2-adrenergic responses without changes in inhibitory G proteins or receptor kinases. J Clin Invest 1998;101:1273-1282.
5[21]Jo SH, Leblais V, Wang PH, Crow MT, Xiao RP. Phosphatidylinositol 3-kinase functionally compartmentalizes the concurrent Gs signaling during β2-adrenergic stimulation. Circ Res 2002; 91:46-53.
6[22]Klauck TM, Faux MC, Labudda K, Langeberg LK, Jaken S,Scott JD. Coordination of three signaling enzymes by AKAP79, a mammalian scaffold protein. Science 1996; 271:1589-1592.
7[23]Fink MA, Zakhary DR, Mackey JA, Desnoyer RW, AppersonHansen C, Damron DS, Bond M. AKAP-mediated targeting of protein kinase A regulates contractility in cardiac myocytes. Circ Res 2001; 88:291-297.
8[24]Shih M, Lin F, Scott JD, Wang HY, Malbon CC. Dynamic complexes of β2-adrenergic receptors with protein kinases and phosphatases and the role of gravin. J Biol Chem 1999;274:1588-1595.
9[25]Lin F, Wang H, Malbon CC. Gravin-mediated formation of signaling complexes in β2-adrenergic receptor desensitization and resensitization. J Biol Chem 2000; 275:19025-19034.
10[26]Fan G, Shumay E, Wang H, Malbon CC. The scaffold protein gravin (cAMP-dependent protein kinase-anchoring protein 250) binds the β2-adrenergic receptor via the receptor cytoplasmic Arg-329 to Leu-413 domain and provides a mobile scaffold during desensitization. J Biol Chem 2001; 276:24005-24014.
1[1]Henkel DM,Witt BJ,Gersh BJ,et al.Ventricular arrhythmias after acute myocardial infarction:a 20-year community study.Am Heart J,2006,151:806-812.
2[2]Lab MJ.Mechanoeleetric feedback (transduction) in heart:concepts and implications.Cardiovasc Res,1996,32:3-14.
3[5]Patten RD,Aronovitz MJ,Deras-Mejia L,et al.Ventricular remodeling in a mouse model of myocardial infarction.Am J Physiol,1998,274:H1812-H1820.
4[6]Walker MJ,Curtis MJ,Campbell RW,et al.The Lambeth Convention:guidelines for the study of arrhythmias in ischemia infarction,and reperfusion.Cardiovasc Res,1986,22:447-455.
5[7]Revens U.Mechano-electric feedback and arrhythmias.Prog Biophys Mol Biol,2003,82:255-266.
6[8]Houle MS,Altschuld RA,Billman GE.Enhanced in vivo and in vitro contractile responses to beta(2)-adrenergic receptor stimulation in dogs susceptible to lethal arrhythmias.J Appl Physiol,2001,91:1627-1637.
7[9]Xiao RP,Avdonin P,Zhou YY,et al.Coupling of beta2-adrenoceptor to Gi proteins and its physiological relevance in murine cardiac myocytes.Circ Res,1999,84:43-52.
8[10]Ruan HM,Mitchell S,Vainoriene M,et al.Gial-mediated cardiac electrophysiological remodeling and arrhythmia in hypertrophic cardiomyopathy.Circulation,2007,116:596-605.
9[11]Xu YJ,Chapman D,Dixon IMC,et al.Differential gene expression in infarct scar and viable myocardium from rat heart following coronary iigation.J Cell Mol Med,2004,8:85-92.
10[12]Xiao RP,Lakatts EG.Betal-adrenoceptor stimulation and beta 2-adrenoceptor stimulation differ in their effects on contraction,cytosolic Ca2+ and Ca2+ current in single rat ventricular cells.Circ Res,1993,73:286-300.
