摘要
利用盐酸-过氧化氢作反应物,通过原位氯化反应合成3-氯丁酮。考察了原料配 比、反应时间、反应温度、及金属盐的加入对反应结果的影响。以CuCl2作催化剂,丁酮、盐酸、过氧 化氢的摩尔配比为2∶1∶1．3时,回流温度下反应5h,丁酮转化率为52．43％,3-氯丁酮选择性 达76％,分馏得到的产品的纯度98％以上。
3-chloro-2-butanone was synthesized by chlorination in situ with HCl-H2O2. The influences of reaction conditions such as mole ratio, reaction time, reaction temperature and some metal salts were examined in detail. The optimum preparation conditions were CuCl2 as catalyst, n（hutanone）：n（HCl）：n（H2O2）=2：1：1.3, reaction temperature 78℃ and reaction time is 5h. the conversion of butanone amount to 52.43%, the selectivity of 3-chloro-2-butanone is over 76% and its purity is over 98%.
出处
《精细化工中间体》
CAS
2005年第5期32-34,共3页
Fine Chemical Intermediates
