C-反应蛋白与冠状动脉粥样硬化病变程度的相关分析

Analysis of the relationship between C-reactive protein and the pathological changes of coronary atherosclerosis

目的探讨C-反应蛋白(CRP)水平与冠状动脉粥样硬化病变程度之间的关系。方法选择住院接受冠状动脉造影检查的病人153例,根据冠脉造影结果分为冠脉正常组(对照组)43例,单支病变组39例,双支病变组32例,三支病变组39例。排除急性心肌梗死及心功能不全、外伤、感染与肿瘤等疾病。入院24 h内空腹抽血,测CRP值。结果CRP在各组间存在显著差异,CRP水平在冠心病各组中均高于正常对照组,单支病变组、双支病变组及三支病变组中CRP水平依次增高。结论CRP与冠脉病变程度呈正相关。

Objective To explore the relationship between C-reactive protein and pathological changes of coronary artery. Methods One hundred and fifty-three patients who had no myocardial infarction, cardiac failure, injury, infection and cancer etc, and were approved by CAG were selected. The patients were retrospected in this study. Forty-three cases of the control group were normal coronary artery, 39 cases with single vessel pathological changes, 32 cases double vessel pathological changes, and 39 cases three vessel pathological changes, which were defined as single, double and three group respectively. The levels serum CRP of all patients were detected within 24 hours. Results There were significant differences among four groups. CRP levels of coronary heart disease were higher than that of control group. Serum CRP levels in three vessel pathological changes were higher than double vessel pathological changes and much higher than single vessel pathological changes. Conclusion Levels of serum CRP is correlated with pathological degree of coronary artery.