复方吡喹酮注射液防治羊脑多头蚴病的试验研究

The experiment study on the treatment of sheep coenosis with the compound praziquantel injection

为了获得复方吡喹酮注射液治疗羊脑多头蚴病的最佳治疗剂量,本试验应用复方吡喹酮注射液30、50、80 mg/kg BW三个剂量组对患羊脑多头蚴病的绵羊进行治疗,设80 mg/kgBW剂量的丙硫咪唑作为药物对照组。试验结果表明,30 mg/kg BW剂量组治愈率较低,为68.97%,不能达到治疗目的;50和80 mg/kg BW剂量对羊脑多头蚴均有很强的驱杀作用,对病羊的治愈率分别为91.84%和92.85%,但两组间差异不显著(P>0.05);高、中剂量组(80、50mg/kg BW)与低剂量组、药物对照组比较差异极显著(P<0.01)。50 mg/kg BW剂量为防治羊脑多头蚴病的最佳治疗剂量。

The compound praziquantel injection was used to treat the sheep coenosis. The three diffenent dosage of 30, 50 and 80 mg/kg BW were used to cure affected sheep in the experiment group, while the albendazole of 80 mg/kg BW was administrated to the affected sheep in the control group. The result indicated that the cure rate with 30 mg/kg BW of compound praziquantel injection was 68.97% ; the dosages of 50 and 80 mg/kg BW could kill the coenurus cerebralis effectively with the cure rates of 91.84% and 92.85% , respectively. There was no significant difference between high and middle dosage groups in cure rates（ P 〉 0. 05 ） , but there were extremely significant differences between the groups of high and middle dosages and the groups of low dosage and the control group（P 〈0. 01 ）. Therefore, 50 mg/kg BW was the best dosage to cure sheep coenosis.