莫达非尼对人体基础+G_z耐力和科里奥利加速度耐力的影响

Effects of modafinil on human basic +G_z tolerance and Coriolis acceleration tolerance

目的观察服用莫达非尼对人体基础+Gz耐力、科里奥利加速度耐力的影响,为飞行人员合理用药提供有关试验依据。方法7名健康青年男性志愿者为受试者,试验分两批:①受试者于8∶00～9∶00交叉服用莫达非尼和安慰剂200mg(相隔1周)后1h进行基础+Gz耐力测定,并在+Gz暴露前后测定受试者的血压和脉搏;②受试者于8∶00～9∶00交叉服用莫达非尼和安慰剂200mg(相隔1周)后1h进行科里奥利加速度耐力的检测。结果服用莫达非尼与安慰剂后1h,两组的基础+Gz耐力分别为3.86±0.24和3.79±0.27、科里奥利加速度耐力分别为25.57±11.67和30.56±10.25,莫达非尼与安慰剂间的观测指标均无明显差异。结论服用莫达非尼200mg起效后对人体基础+G耐力和抗运动病能力均无明显不良影响。

Objective To observe the effects of modafinil on human basic ＋Gz tolerance and Coriolis acceleration tolerance. Methods Seven healthy young male volunteers served as subjects. The experiment was divided into two parts： ① subjects administered modafinil （200mg） or placebo at 8 ： 00～9 ： 00 a.m. alternatively with one week interval, and their basic ＋Gz tolerance was measured 1 h later. Blood pressure and pulse rate were obtained immediately before and after the G-tolerance test. ② subjects administered modafinil （200 mg）or placebo at 8 ： 00～9 ： 00 a.m. alternatively with one week interval, and their Coriolis acceleration tolerance was measured 1 h later. Results The G tolerance of modafinil group and control group was 3.86 ± 0.24 and 3.79 ±0.27 respectively; and their Coriolis acceleration tolerance was 25.57 ±11.67 and 30.56 ± 10. 25 separately. The differences between modafinil group and control group were both non-significant. Conclusions No significant adverse effects on human basic ＋ Gz tolerance and antimotion sickness ability were found 1 h after taking modafinil 200 mg.